Biol. Col : 19989-M
Manuel de la Mata. Precision, Preventive and Personalized Medicine. Geneticist | Product Manager and genetic consultant at 24Genetics.
Manuel de la Mata, MsC. He is a young geneticist and genetic counselor, a biologist specialized in clinical genetics and fertility. Currently, he continues his active training, both self-taught and through institutions, symposia and international congresses.
He began his professional career rotating at the RamĆ³n y Cajal Hospital, one of the pioneering hospitals in Spain in the area of clinical genetics. It was through this experience, when he learned and realized about the potential and passion that genetics held.
Subsequently, he made the leap to 24Genetics, in the early days of the company. His role has been focused on the product development and genetic counseling department for the last two years.
Manuel has been a member of several societies such as: The European Society of Human Genetics, the Spanish Society of Human Genetics and of the Spanish Society of Genetic Counseling.
Ā
FOCUS AREAS
Ā
EDUCATION
MĆSTER
Clinical Genetics and Assisted Reproduction
DEGREE
Degree in Biology
Ā
RESEARCH
An individual's genetic makeup contributes to susceptibility and response to viral infection. Although environmental, clinical, and social factors play a role in SARS-CoV-2 exposure and severity of COVID-191,2 disease, host genetics may also be important. Identification of host-specific genetic factors may reveal therapeutically important biological mechanisms and elucidate causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of investigators to investigate the role of human genetics in SARS-CoV-2 infection and the severity of COVID-19. We describe the results of three genome-wide association meta-analyses covering up to 49,562 patients with COVID-19 from 46 studies in 19 countries. We report 13 significant genome-wide loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations with pulmonary or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body mass index for severe COVID-19, although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19, with unprecedented speed, was made possible by the human genetics research community coming together to prioritize the sharing of data, results, resources, and analytical frameworks. This model of international collaboration highlights the potential for future genetic discoveries in emerging pandemics or, indeed, any complex human disease.
Ā
COURSES
Ā
ADDITIONAL CONTENTS:
http://revbigo.webs.uvigo.es/images/revbigo/2016/Revbigo_2016_07.pdf
In the digital age, technology is advancing by leaps and bounds and this has allowed the understanding of our genetics to reach unprecedented levels. In this fascinating journey of self-discovery, we at 24Genetics are proud to be at the forefront, offering you insight...
From the color of our eyes to our predispositions to certain diseases, our genes significantly influence our lives. Thanks to technological advances and industry-leading companies like 24Genetics, personalized genetics is now more accessible than ever.Ā What is...
What is Gaucher disease? Gaucher disease is a rare autosomal recessive (two copies of a mutated gene must be present for the disease to develop) genetic disorder, which is due to a deficit of a lysosomal enzyme called glucocerebrosidase, which causes the storage of...
TheĀ pancreasĀ is a glandular organ behind the stomach and in front of the spine. It produces gastric juices, enzymes that break down food, and several hormones that help control blood glucose levels. A tumor starts developing when thereās an abnormal growth of the...
TheĀ lymphatic systemĀ is vital to the human body's immune system. It produces and transports lymph cells throughout the bloodstream and acts in the event of infections or other diseases [1].Ā It comprises an extensive network of lymphatic vessels branching through...
Coronary artery disease isĀ one of the leading causes of mortality worldwide. It's the most common type of heart disease. Although there are known risk factors, such as smoking, high cholesterol, and hypertension,Ā numerous studies have shown that genetics play an...
Rare diseases are characterized by their low prevalence, which is defined as the number of people in a specific group who suffer from a certain disease at a specific time.Ā While there is no single definition for the term "rare disease," they are all based on the...
Itās important to understand the factors that can put brain health at risk. Research has shown that both environmental and genetic factors can increase the risk of an intracranial aneurysm, a weakened area in a blood vessel in the brain that causes it to dilate or...
Rheumatoid arthritis falls into a very broad group of pathologies called autoimmune diseases. These chronic conditions are characterized by the immune system attacking its own tissues and organs, which can occur anywhere in the body.Ā The exact cause of autoimmune...
Skin cancer is one of the most common types of cancer that exist. It usually appears in the areas of the skin most exposed to the sun, such as the head, neck or back, although it can appear anywhere on the body. Skin cancer is mainly classified into three types: basal...
